Scientific Report: invisa-RED® vs. Zerona Z6/VZ8 405nm Laser Systems

Title

Scientific Analysis of Wavelength, Energy Absorption, and Efficacy in Non-Invasive Fat Reduction: A Comparative Study of invisa-RED® and Zerona Z6/VZ8 405nm Violet Laser Systems

Abstract

This report presents a comprehensive analysis comparing the invisa-RED® dual-wavelength pulsed laser system (680nm and 980nm) with the 405nm violet laser systems such as the Zerona Z6/VZ8. Emphasis is placed on light absorption in adipose tissue, laser delivery methods, energy per photon, tissue penetration depth, and clinical outcomes. The findings support the conclusion that invisa-RED® offers superior fat reduction results due to its optimized wavelength, pulsed delivery method, and proven mitochondrial activation.

1. Introduction

Non-invasive laser-based body contouring has become increasingly popular. While many devices claim efficacy, scientific validation remains limited for some. This paper investigates the physiological, biophysical, and clinical basis for fat loss using photobiomodulation (PBM), with a focus on comparing invisa-RED®'s 680nm and 980nm pulsed laser system to Zerona’s Z6/VZ8 405nm continuous violet lasers.

2. Understanding Photobiomodulation in Fat Reduction

Photobiomodulation (PBM) relies on delivering low-level laser energy to target intracellular mitochondria. When cytochrome c oxidase (CCO), a mitochondrial enzyme, absorbs specific wavelengths, it increases ATP production, opening transient pores in adipocytes and triggering lipolysis.- Red (630-680nm) and near-infrared (800-980nm) wavelengths are ideal for PBM due to their deep tissue penetration and resonance with CCO.- Violet light (405nm), while higher in photon energy, is absorbed primarily by surface structures (melanin, hemoglobin), limiting its reach to <0.5mm.

3. Wavelength and Tissue Penetration

The ability of light to reach subcutaneous fat depends on its absorption and scattering properties in biological tissue.405nm (~3.1 eV) - Penetrates ~0.3-0.5 mm, absorbed by melanin/hemoglobin. Not effective for adipose.680nm (~1.82 eV) - Reaches ~5-10 mm, well absorbed by cytochrome c oxidase.980nm (~1.27 eV) - Reaches ~20-40 mm, ideal for deep tissue stimulation.References: Karu (2010), Avci et al. (2013), Ash et al. (2017)

4. Energy and Photonic Delivery Comparison

Laser systems emit photons at specific wavelengths. Photon energy is calculated as:E (eV) = 1240 / lambda (nm)405nm @ 23 mW emits ~4.63  10^16 photons/sec680nm @ 200 mW emits ~6.87  10^17 photons/sec980nm @ 200 mW emits ~9.85  10^17 photons/sec

5. Pulsed vs Continuous Wave Lasers

Continuous wave (CW) lasers deliver constant light energy. Pulsed lasers, like invisa-RED®, deliver bursts of light with delay intervals (photobleaching), which:- Prevents receptor saturation in mitochondria (CCO)- Enhances sustained ATP production- Minimizes tissue heatingEvidence: Karu & Kolyakov (2005); Hashmi et al. (2010)

6. Clinical Efficacy Comparison

invisa-RED® (NCT03811093):- ~10.16 inches circumference lost- ~4.5 lbs fat mass lost- ~1.75% drop in body fat %Zerona Z6/VZ8 (NCT05674292):- ~3.91 inches lost- No fat % or mass loss

7. Absorption Coefficients in Adipose Tissue

Absorption coefficient (µa) describes how effectively a specific tissue absorbs light at a given wavelength. For fat reduction, light must penetrate the skin and be absorbed in adipocytes to stimulate lipolysis.Based on studies by van Veen et al. (2004), Bashkatov et al. (2005), and Jacques (2013), we observe the following:

Wavelength	Absorption Coefficient(µa) in Fat	Penetration	Target Structure	Effectiveness
405nm	~0.15 - 0.25	<0.5 mm	Melanin, Hemoglobin (Surface)	Not Effective
680nm	~0.025 - 0.05	5-10 mm	CCO Mitochondria	Effective
980nm	~0.03 – 0.06	20-40 mm	Deep Fat, Water, Vascular Tissue	Very Effective

These values demonstrate that 680nm and 980nm wavelengths used by invisa-RED® have superior transmission and bioavailability in adipose tissue compared to 405nm, which is limited to surface-level interaction.References:1. van Veen RLP, et al. OMLC, 20042. Bashkatov AN, et al. Optical Properties of Subcutaneous Adipose Tissue, 20053. Jacques SL. Phys Med Biol. 2013

8. Conclusion

invisa-RED® is the only system combining optimal wavelength, power output, pulsed delivery, and clinically validated fat loss. 405nm lasers do not reach adipose tissue and cannot stimulate mitochondrial lipolysis.

References

1. Karu T. Photochem Photobiol Sci. 20102. Avci P, et al. Semin Cutan Med Surg. 20133. Ash C, et al. Lasers Med Sci. 20174. Karu & Kolyakov. Photochem Photobiol Sci. 20055. Hashmi JT, et al. Lasers Surg Med. 20106. ClinicalTrials.gov - NCT038110937. ClinicalTrials.gov - NCT056742928. van Veen et al. OMLC, 20049. Bashkatov AN, et al. Optical Properties of Subcutaneous Adipose Tissue. 2005